Stereoselective Borylative Ketone-Diene Coupling
Hee Yeon Cho, Zhiyong Yu and James P. Morken*
*Department of Chemisty, Merkert Chemistry Center, 2609 Beacon Street, Boston College, Chestnut Hill, Massachusetts 02467, United States, Email: morkenbc.edu
H. Y. Cho, Z. Yu, J. P. Morken, Org. Lett., 2011, 13, 5267-5269.
DOI: 10.1021/ol202138v (free Supporting Information)
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Ketones, dienes, and B2(pin)2 undergo a stereoselective multicomponent coupling reaction in the presence of catalytic amounts of Ni(cod)2 and P(t-Bu)3. A subsequent oxidation furnishes 1,3-diols as the major reaction product.
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