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Rhodium(I)-Catalyzed 1,4-Addition of Arylboronic Acids to Acrylic Acid in Water: One-Step Preparation of 3-Arylpropionic Acids

Nicolas R. Vautravers, Bernhard Breit*

*Institut für Organische Chemie und Biochemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104 Freiburg, Germany, Email: bernhard.breitchemie.uni-freiburg.de

N. R. Vautravers, B. Breit, Synlett, 2011, 2517-2520.

DOI: 10.1055/s-0030-1260319


Abstract

A practical method for the one-step preparation of 3-arylpropionic acids through rhodium-catalyzed 1,4-addition of arylboronic acids to acrylic acid is applicable to a broad scope of aryl boronic acids and displays a wide functional group tolerance operating in water as the optimal reaction medium.

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Key Words

boronic acids, acrylic acid, water, conjugate addition, rhodium


ID: J60-Y2011-2990