Copper-Catalyzed C(sp³)-C(sp³) Bond Formation Using a Hypervalent Iodine Reagent: An Efficient Allylic Trifluoromethylation

Xi Wang, Yuxuan Ye, Songnan Zhang, Jiajie Feng, Yan Xu, Yan Zhang and Jianbo Wang*

*Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China, Email: wangjbpku.edu.cn

X. Wang, Y. Ye, S. Zhang, J. Feng, Y. Xu, Y. Zhang, J. Wang, J. Am. Chem. Soc., 2011, 133, 16410-16413.

DOI: 10.1021/ja207775a

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Abstract

An efficient copper-catalyzed allylic trifluoromethylation reaction of alkenes with a hypervalent iodine (III) reagent (Togni reagent) provides a general and straightforward way to synthesize allylic trifluoromethylated compounds under mild conditions.

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Key Words

allylic trifluoromethanes

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ID: J48-Y2011-3000