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An Efficient and General Method for the Heck and Buchwald-Hartwig Coupling Reactions of Aryl Chlorides

Dong-Hwan Lee, Abu Taher, Shahin Hossain and Myung-Jong Jin*

*Department of Chemical Science and Engineering, Inha University, Incheon 402-751, South Korea, Email: mjjininha.ac.kr

D.-H. Lee, A. Taher, S. Hossain, M.-J. Jin, Org. Lett., 2011, 13, 5540-5543.

DOI: 10.1021/ol202177k (free Supporting Information)



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Abstract

A β-diketiminatophosphane Pd complex acted as a powerful catalyst for the Heck coupling of various aryl chlorides with alkenes under relatively mild conditions. Furthermore, this catalytic system also proved to be highly active in the Buchwald-Hartwig coupling of deactivated and sterically hindered aryl chlorides at room temperature.

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Key Words

Heck Reaction


ID: J54-Y2011-3040