A Mild and Efficient Route to 2-Azetidinones Using the Cyanuric Chloride-DMF Complex

Maaroof Zarei, Aliasghar Jarrahpour*

*Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran, Email: jarrahsusc.ac.ir

M. Zarei, A. Jarrahpour, Synlett, 2011, 2572-2576.

DOI: 10.1055/s-0030-1289517

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Abstract

Efficient conversion of Schiff bases and carboxylic acids to β-lactams can be carried out at room temperature in CH₂Cl₂, using a cyanuric chloride-N,N-dimethyl formamide complex. The complex is easily prepared by reaction of cyanuric chloride and DMF at room temperature.

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Key Words

2-azetidinones, β-lactams, Staudinger synthesis, cyanuric chloride, Schiff base

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ID: J60-Y2011-3150