N-Bromosuccinimide Promoted One-Pot Synthesis of Guanidine: Scope and Mechanism
Ling Zhou, Jie Chen, Jing Zhou and Ying-Yeung Yeung*
*3 Science Drive 3, Department of Chemistry, National University of Singapore, Singapore 117543, Email: chmyyynus.edu.sg
L. Zhou, J. Chen, J. Zhou, Y.-Y. Yeung, Org. Lett., 2011, 13, 5804-5807.
DOI: 10.1021/ol202402y (free Supporting Information)
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A novel electrophilic one-pot reaction of an olefin, a cyanimide, an amine, and N-bromosuccinimide enables the synthesis of a number of guanidine derivatives with very good yields - including an rTRTVI precursor.
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L. Zhou, J. Zhou, C. K. Tan, J. Chen, Y.-Y. Yeung, Org. Lett., 2011, 13, 2448-2451.