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Palladium-Catalyzed 1,4-Addition of Diarylphosphines to α,β-Unsaturated Aldehydes

Yun-Rong Chen and Wei-Liang Duan*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email: wlduanmail.sioc.ac.cn

Y.-R. Chen, W.-L. Duan, Org. Lett., 2011, 13, 5824-5826.

DOI: 10.1021/ol2024339 (free Supporting Information)


Abstract

A highly stereoselective asymmetric 1,4-addition of diarylphosphines to α,β-unsaturated aldehydes catalyzed by a bis(phosphine) pincer-Pd complex enables the synthesis of chiral phosphines with excellent stereoselectivity under mild conditions.

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Key Words

Phosphines, Borane


ID: J54-Y2011-3220