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Rare-Earth-Catalyzed C-H Bond Addition of Pyridines to Olefins

Bing-Tao Guan and Zhaomin Hou*

*Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan, Email: houzriken.jp

B.-T. Guan, Z. Hou, J. Am. Chem. Soc., 2011, 133, 18066-18089.

DOI: 10.1021/ja208129t (free Supporting Information)


Abstract

Cationic half-sandwich rare-earth catalysts provide an efficient, general and atom-economical method for the synthesis of 2-alkylated pyridine derivatives via C-H addition to olefins. A wide range of pyridine and olefin substrates including α-olefins, styrenes, and conjugated dienes are compatible with the catalysts.


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Key Words

pyridines


ID: J48-Y2011-3250