Palladium-Catalyzed Hiyama Cross-Coupling of Aryltrifluorosilanes with Aryl and Heteroaryl Chlorides
Gary A. Molander* and Laura Iannazzo
*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States, Email: gmolandrsas.upenn.edu
G. A. Molander, L. Iannazzo, J. Org. Chem., 2011, 76, 9102-9108.
DOI: 10.1021/jo201840n (free Supporting Information)
An efficient, palladium-catalyzed Hiyama cross-coupling reaction of aryltrifluorosilanes with aryl chlorides enables the preparation of various functionalized biaryl derivatives in good to excellent yields. The scope of this reaction has also been extended to heteroaryl chlorides, affording the corresponding heterobiaryl compounds in high yields.
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