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TEMPO Oxoammonium Salt-Mediated Dehydrogenative Povarov/Oxidation Tandem Reaction of N-Alkyl Anilines

Heinrich Richter and Olga García Mancheño*

*Organisch-Chemisches Institut, Münster University, Corrensstrasse 40, 48149 Münster, Germany, Email:

H. Richter, O. G. Mancheño, Org. Lett., 2011, 13, 6066-6069.

DOI: 10.1021/ol202552y (free Supporting Information)

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A one-pot dehydrogenative Povarov/oxidation tandem reaction of N-alkyl anilines with mono- and 1,2-disubstituted aryl and alkyl olefins enables the synthesis of a various substituted quinolines. The simple protocol uses cheap and benign iron(III)chloride as the Lewis acid catalyst and a TEMPO oxoammonium salt as a nontoxic, mild, efficient oxidant.

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Key Words

Quinolines, TEMPO

ID: J54-Y2011-3350