Organic Chemistry Portal



Direct Condensation of Sulfonamide and Formamide: NaI-Catalyzed Synthesis of N-Sulfonyl Formamidine Using TBHP as Oxidant

Shulin Chen, Yuan Xu and Xiaobing Wan*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China, Email:

S. Chen, Y. Xu, X. Wan, Org. Lett., 2011, 13, 6152-6155.

DOI: 10.1021/ol2024604 (free Supporting Information)


NaI-catalyzed direct condensation of sulfonamides and formamides enables N-sulfonyl formamidine synthesis without hazardous reagents or transition-metal catalysts. The green methodology features high atom economy, operational simplicity, and good tolerance with diverse functional groups.

see article for more examples

Key Words

amidines, TBHP, Green Chemistry

ID: J54-Y2011-3400