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High-Yielding Oxidation of β-Hydroxyketones to β-Diketones Using o-Iodoxybenzoic Acid

Samuel L. Bartlett and Christopher M. Beaudry*

*Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331, United States, Email: christopher.beaudryoregonstate.edu

S. L. Bartlett, C. M. Beaudry, J. Org. Chem., 2011, 76, 9852-9855.

DOI: 10.1021/jo201810c (free Supporting Information)


Abstract

In oxidation of β-hydroxyketones to β-diketones, o-iodoxybenzoic acid (IBX) was found to be efficient, operationally easy, and superior to other common oxidants. The reaction is suitable for milligram- to gram-scale oxidations.


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Key Words

β-diketones, IBX


ID: J42-Y2011-3480