Phase Separation As a Strategy Toward Controlling Dilution Effects in Macrocyclic Glaser-Hay Couplings
Anne-Catherine Bédard and Shawn K. Collins*
*Département de Chimie, Centre for Green Chemistry and
Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec
H3C 3J7 Canada, Email: shawn.collins
umontreal.ca
A.-C. Bédard, S. K. Collins, J. Am. Chem. Soc., 2011, 133, 19976-19981.
DOI: 10.1021/ja208902t
Abstract
Phase separation of the catalyst and substrate enables a macrocyclization strategy conducted at high concentrations. PEG400, a green and efficient solvent can be utilized in biphasic mixtures for promoting macrocyclization based on Glaser-Hay coupling at high concentrations with copper complexes, that are soluble in this highly polar phase.
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Key Words
ID: J48-Y2011-3530
