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Kumada Coupling of Aryl, Heteroaryl, and Vinyl Chlorides Catalyzed by Amido Pincer Nickel Complexes

Ning Liu and Zhong-Xia Wang*

*CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Email: zxwangustc.edu.cn

N. Liu, Z.-X. Wang, J. Org. Chem., 2011, 76, 10031-10032.

DOI: 10.1021/jo201821g (free Supporting Information)



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Abstract

P,N,O-pincer nickel complexes are active catalysts for the Kumada coupling of aryl, heteroaryl, and vinyl chlorides with aryl Grignard reagents. The cross-couplings can proceed at room temperature and tolerate functional groups in aryl chlorides with the aid of LiCl and ZnCl2 additives.

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Amido Pincer Nickel Catalyzed Kumada Cross-Coupling of Aryl, Heteroaryl, and Vinyl Chlorides

X.-Q. Zhang, Z.-X. Wang, Synlett, 2013, 24, 2081-2084.

Cross-Coupling of ArX with ArMgBr Catalyzed by N-Heterocyclic Carbene-Based Nickel Complexes

N. Liu, Z.-X. Wang, J. Org. Chem., 2011, 76, 10031-10032.


Key Words

Kumada Coupling


ID: J42-Y2011-3640