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CuCl/DABCO/4-HO-TEMPO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted Quinazolines and 4H-3,1-Benzoxazines

Bing Han*, Xiu-Long Yang, Chao Wang , Yong-Wei Bai, Tai-Chao Pan, Xin Chen and Wei Yu*

*State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Street, Lanzhou 730000, P. R. China, Email: hanblzu.edu.cn, yuweilzu.edu.cn

B. Han, X.-L. Yang, C. Wang, Y.-W. Bai, T.-C. Pan, X. Chen, W. Yu, J. Org. Chem., 2012, 77, 1136-1142.

DOI: 10.1021/jo2020399 (free Supporting Information)


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Abstract

CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant enabled an efficient aerobic oxidative synthesis of 2-substituted quinazolines and 4H-3,1-benzoxazines from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively.


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Key Words

quinazolines, 4H-3,1-benzoxazines, TEMPO, oxygen


ID: J42-Y2012-0140