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Magnetic Nano-Fe3O4-Supported 1-Benzyl-1,4-dihydronicotinamide (BNAH): Synthesis and Application in the Catalytic Reduction of α,β-Epoxy Ketones

Hua-Jian Xu*, Xin Wan, Yong-Ya Shen, Song Xu and Yi-Si Feng*

*School of Medical Engineering, School of Chemical Engineering, Hefei University of Technology, Hefei 230009, P. R. China, Email:,

H.-J. Xu, X. Wan, Y.-Y. Shen, S. Xu, Y.-S. Feng, Org. Lett., 2012, 14, 1210-1213.

DOI: 10.1021/ol203423u (free Supporting Information)

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The of silica-coated magnetic nanoparticles allowed the construction of magnetically recoverable organic hydride compounds. Magnetic nanoparticle-supported BNAH (1-benzyl-1,4-dihydronicotinamide) showed efficient activity in the catalytic reduction of α,β-epoxy ketones. After reaction, the catalyst can be separated by simple magnetic separation and can be reused.

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Catalytic Hydrogenation of α,β-Epoxy Ketones to Form β-Hydroxy Ketones Mediated by an NADH Coenzyme Model

H.-J. Xu, Y.-C. Liu, Y. Fu, Y.-D. Wu, Org. Lett., 2006, 8, 3449-3451.

Key Words

Reduction of Epoxides, Sodium Hydrosulfite, Organocatalysis, Green Chemistry

ID: J54-Y2012-0530