Silver-Catalyzed Decarboxylative Chlorination of Aliphatic Carboxylic Acids
Zhentao Wang, Lin Zhu, Feng Yin, Zhongquan Su, Zhaodong Li and Chaozhong Li*
*Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People’s Republic of China, Email: cligmail.sioc.ac.cn
Z. Wang, L. Zhu, F. Yin, Z. Su, Z. Li, C. Li, J. Am. Chem. Soc., 2012, 134, 4258-4263.
DOI: 10.1021/ja210361z (free Supporting Information)
An efficient, catalytic Hunsdiecker reaction of aliphatic carboxylic acids affords the corresponding chlorodecarboxylation products in high yields under mild conditions in the presence of t-butyl hypochlorite and Ag(Phen)2OTf as catalyst. The reaction exhibits remarkable functional group compatibility.
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