Organic Chemistry Portal

Abstracts

Search:

Palladium-Catalyzed Approach to Primary Amides Using Nongaseous Precursors

Dennis U. Nielsen, Rolf H. Taaning, Anders T. Lindhardt*, Thomas M. Gøgsig and Troels Skrydstrup*

*Center for Insoluble Protein Structure (inSPIN), Department of Chemistry, Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark, Email: lindhardtchem.au.dk, tschem.au.dk

D. U. Nielsen, R. H. Taaning, A. T. Lindhardt, T. M. Gøgsig, T. Skrydstrup, Org. Lett., 2011, 13, 4454-4457.

DOI: 10.1021/ol201808y


see article for more reactions

Abstract

Pd-catalyzed carbonylation chemistry applying a two-chamber system with crystalline and nontransition metal based sources of carbon monoxide and ammonia is suitable for the synthesis of various primary amides with good functional group tolerance. This approach is also useful for accessing carbon isotope labeled derivatives.

see article for more examples



Palladium Catalyzed Carbonylative Heck Reaction Affording Monoprotected 1,3-Ketoaldehydes

T. M. Gøgsig, D. U. Nielsen, A. T. Lindhardt, T. Skrydstrup, Org. Lett., 2012, 14, 2536-2539.

Palladium-Catalyzed N-Acylation of Monosubstituted Ureas Using Near-Stoichiometric Carbon Monoxide

K. Bjerglund, A. T. Lindhardt, T. Skrydstrup, J. Org. Chem., 2012, 77, 3793-3799.


Key Words

Aminocarbonylation


ID: J54-Y2011-3650