Copper-Catalyzed Aerobic Intramolecular Carbo- and Amino-Oxygenation of Alkynes for Synthesis of Azaheterocycles
Kah Kah Toh, Stephen Sanjaya, Sophian Sahnoun, Sin Yee Chong and Shunsuke Chiba*
*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore, Email: shunsukentu.edu.sg
K. K. Toh, S. Sanjaya, S. Sahnoun, S. Y. Chong, S. Chiba, Org. Lett., 2012, 14, 2290-2292.
DOI: 10.1021/ol3007106 (free Supporting Information)
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Cu-catalyzed aerobic cyclization of N-(2-alkynylaryl)enamine carboxylates via intramolecular carbo-oxygenation of alkynes gives highly substituted quinolines. This strategy was further applied for N-alkynylamidines leading to imidazole and quinazoline derivatives.
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