Palladium Catalyzed Carbonylative Heck Reaction Affording Monoprotected 1,3-Ketoaldehydes
Thomas M. Gøgsig, Dennis U. Nielsen, Anders T. Lindhardt and Troels Skrydstrup*
*Center for Insoluble Protein Structure (inSPIN), Department of Chemistry, Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark, Email: tschem.au.dk
T. M. Gøgsig, D. U. Nielsen, A. T. Lindhardt, T. Skrydstrup, Org. Lett., 2012, 14, 2536-2539.
DOI: 10.1021/ol300837d
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Abstract
A palladium catalyzed carbonylation of aryl iodides using near stoichiometric amounts of carbon monoxide enables the synthesis of monoprotected 1,3-ketoaldehydes. Besides representing platforms for a variety of heterocyclic structures, these motives serve as viable precursors for the highly relevant aryl methyl ketones.
see article for more examples
K. T. Neumann, S. R. Laursen, A. T. Lindhardt, B. Bang-Andersen, T. Skrydstrup, Org. Lett., 2014, 16, 2216-2219.
Palladium-Catalyzed Approach to Primary Amides Using Nongaseous Precursors
D. U. Nielsen, R. H. Taaning, A. T. Lindhardt, T. M. Gøgsig, T. Skrydstrup, Org. Lett., 2011, 13, 4454-4457.
Key Words
ID: J54-Y2012-1590