Discovery of A Novel Palladium Catalyst for the Preparation of Enynes with a Copper- and Ligand-Free Sonogashira Reaction

Xia Mi, Mengmeng Huang*, Yujian Feng, Yangjie Wu*

*Chemistry Department, Zhengzhou University, Zhengzhou 450052, P. R. of China, Email: wyjzzu.edu.cn, hmmzzu.edu.cn

X. Mi, M. Huang, Y. Feng, Y. Wu, Synlett, 2012, 23, 1257-1261.

DOI: 10.1055/s-0031-1290938

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Abstract

A palladium(II) complex based on N,N-dimethylethanolamine can be used as a catalyst in copper-free Sonogashira couplings of (E)- or (Z)-bromostyrenes with alkynes to produce conjugated enynes at room temperature in good yields with retention of the configuration.

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Key Words

N,N-dimethylethanolamine, copper-free, Sonogashira reaction, enynes, β-bromostyrenes, stereochemistry

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ID: J60-Y2012-1620