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Amphiphilic Self-Assembled Polymeric Copper Catalyst to Parts per Million Levels: Click Chemistry

Yoichi M. A. Yamada*, Shaheen M. Sarkar and Yasuhiro Uozumi*

*RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan, Email: ymayamadariken.jp, uoims.ac.jp

Y. M. A. Yamada, S. M. Sarkar, Y. Uozumi, J. Am. Chem. Soc., 2012, 134, 9285-9286.

DOI: 10.1021/ja3036543 (free Supporting Information)


Abstract

Self-assembly of copper sulfate and a poly(imidazole-acrylamide) amphiphile provides a highly active, reusable, globular, solid-phase catalyst for click chemistry. The insoluble amphiphilic polymeric imidazole Cu catalyst drove the cycloaddition of various of alkynes and organic azides at very low catalyst loadings and can be readily reused without loss of activity to give the corresponding triazoles quantitatively.

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Key Words

click chemistry, 1,2,3-triazoles, green chemistry, multicomponent reactions


ID: J48-Y2012-1830