Amphiphilic Self-Assembled Polymeric Copper Catalyst to Parts per Million Levels: Click Chemistry
Yoichi M. A. Yamada*, Shaheen M. Sarkar and Yasuhiro Uozumi*
*RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan, Email: ymayamadariken.jp, uoims.ac.jp
Y. M. A. Yamada, S. M. Sarkar, Y. Uozumi, J. Am. Chem. Soc., 2012, 134, 9285-9286.
DOI: 10.1021/ja3036543 (free Supporting Information)
Self-assembly of copper sulfate and a poly(imidazole-acrylamide) amphiphile provides a highly active, reusable, globular, solid-phase catalyst for click chemistry. The insoluble amphiphilic polymeric imidazole Cu catalyst drove the cycloaddition of various of alkynes and organic azides at very low catalyst loadings and can be readily reused without loss of activity to give the corresponding triazoles quantitatively.
see article for more examples