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Potassium tert-Butoxide Promoted Cycloaddition Reaction for the Synthesis of 1,5-Disubstituted 1,2,3-Triazoles from Aromatic Azides and Trimethylsilyl-Protected Alkynes

Luyong Wu*, Yuxue Chen, Mi Tang, Xinming Song, Guangying Chen, Xiaoping Song, Qiang Lin

*College of Chemistry and Chemical Engineering, Hainan Normal University, No.99, Longkun South Road, Haikou 571158, P. R. of China, Email: wuluyonghainnu.edu.cn

L. Wu, X. Chen, M. Tang, X. Song, G. Chen, X. Song, Q. Lin, Synlett, 2012, 23, 1529-1533.

DOI: 10.1055/s-0031-1291042 (free Supporting Information)


Abstract

The use of t-BuOK in wet DMF as desilylating reagent in a cycloaddition reaction of aromatic azides and trimethylsilyl alkynes generated 1,5-disubstituted 1,2,3-triazoles regioselectively in good yields at ambient temperature.

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Key Words

alkynes, azides, cycloaddition, 1,2,3-triazoles, desilylation


ID: J60-Y2012-2000