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S-Benzyl Isothiouronium Chloride as a Recoverable Organocatalyst for the Direct Reductive Amination of Ketones with Hantzsch Ester

Quynh Pham Bao Nguyen, Taek Hyeon Kim*

*School of Applied Chemical Engineering and Center for Functional Nano Fine Chemicals, College of Engineering, Chonnam National University, Gwangju 500-757, Republic of Korea, Email: thkimchonnam.ac.kr

Q. P. B. Nguyen, T. H. Kim, Synthesis, 2012, 44, 1977-1982.

DOI: 10.1055/s-0031-1291125 (free Supporting Information)


Abstract

A direct reductive amination of ketones using the Hantzsch ester in the presence of S-benzyl isothiouronium chloride as a recoverable organocatalyst converts a wide range of ketones as well as aryl amines to the expected products in good yields.


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Key Words

S-benzyl isothiouronium chloride, reductive amination, ketones, aryl amines, hydrogen bond, Hantzsch ester, Organocatalysis


ID: J66-Y2012-2070