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Activation of H2O2 by Chiral Confined Brønsted Acids: A Highly Enantioselective Catalytic Sulfoxidation

Saihu Liao, Ilija Čorić, Qinggang Wang and Benjamin List*

*Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Email: listkofo.mpg.de

S. Liao, I. Čorić, Q. Wang, B. List, J. Am. Chem. Soc., 2012, 134, 10765-10768.

DOI: 10.1021/ja3035637 (free Supporting Information)


Abstract

Confined chiral Brønsted acids catalyze asymmetric oxidations of a broad range of sulfides to sulfoxides with hydrogen peroxide. The wide generality and high enantioselectivity of the developed method is comparable even to the best metal-based systems.


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Key Words

Sulfoxides, hydrogen peroxide, organocatalysis


ID: J48-Y2012-2100