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An Acid-Catalysed Hydroamination Approach to Isoindolines

Laura Henderson, David W. Knight*, Andrew C. Williams

*School of Chemistry, Cardiff University, Main College, Park Place, Cardiff, CF10 3AT, UK, Email: knightdwcf.ac.uk

L. Henderson, D. W. Knight, A. C. Williams, Synlett, 2012, 23, 1667-1669.

DOI: 10.1055/s-0031-1291155 (free Supporting Information)


Abstract

Acid-catalysed intramolecular hydroamination of 2-alkenylarylethylamine derivatives gives smoothly isoindolines via benzylic carbenium ion generation.

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Key Words

cyclisation, sulfonamides, hydroamination, isoindolines


ID: J60-Y2012-2260