Copper(II)-Mediated Dehydrogenative Cross-Coupling of Heteroarenes
Zhifeng Mao, Zhe Wang, Zhaoqing Xu*, Fei Huang, Zhengkun Yu* and Rui Wang*
*Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China, and Lanzhou University, Lanzhou 730000, China, Email: xuzqdicp.ac.cn, zkyudicp.ac.cn, wangruilzu.edu.cn
Z. F. Mao, Z. Wang, Z. Q. Xu, F. Huang, Z. K. Yu, R. Wang, Org. Lett., 2012, 14, 3854-3857.
DOI: 10.1021/ol301517y
Abstract
The use of Cu(OAc)2 enables a dehydrogenative cross-coupling between two heteroarenes via disproportionation of the copper mediator. This synthetic protocol provides a concise and "green" access to unsymmetrical biheteroarenes bearing structural motifs of substantial utility in organic synthesis.
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ID: J54-Y2012-2410