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Nickel-Mediated N-Arylation with Arylboronic Acids: An Avenue to Chan-Lam Coupling

Dushyant Singh Raghuvanshi, Amit Kumar Gupta and Krishna Nand Singh*

*Department of Chemistry (Centre of Advanced Study), Faculty of Science, Banaras Hindu University, Varanasi 221005, India, Email: knsinghbhuyahoo.co.in

D. S. Raghuvanshi, A. K. Gupta, K. N. Singh, Org. Lett., 2012, 14, 4326-4329.

DOI: 10.1021/ol3021836 (free Supporting Information)


Abstract

NiCl2 6 H2O is an efficient catalyst for the cross-coupling of arylboronic acids with various N-nucleophiles. The method is practical and offers an alternative to the corresponding Cu-mediated Chan-Lam coupling.

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Key Words

Chan-Lam Coupling, Anilines


ID: J54-Y2012-2780