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pH-Independent Transfer Hydrogenation in Water: Catalytic, Enantioselective Reduction of β-Keto Esters

Martin A. Ariger and Erick M. Carreira*

*Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, Switzerland, Email: carreiraorg.chem.ethz.ch

M. A. Ariger, E. M. Carreira, Org. Lett., 2012, 14, 4522-4524.

DOI: 10.1021/ol301903c (free Supporting Information)


Abstract

A pH-independent asymmetric transfer hydrogenation of β-keto esters in water with formic acid/sodium formate can be conducted open to air and gives access to β-hydroxy esters in excellent yields and selectivities.

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Key Words

Formic Acid, Reduction of Carbonyl Compounds, β-Hydroxy Esters


ID: J54-Y2012-2890