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Fischer Indole Synthesis in Low Melting Mixtures

Sangram Gore, Sundarababu Baskaran* and Burkhard König*

*Indian Institute of Technology-Madras, Chennai 600036, India; Universität Regensburg, D-93040, Regensburg, Email: sbhaskariitm.ac.in, burkhard.koenigchemie.uni-regensburg.de

S. Gore, S. Baskaran, B. König, Org. Lett., 2012, 14, 4568-4571.

DOI: 10.1021/ol302034r (free Supporting Information)


Abstract

Functionalized indoles are synthezised under mild conditions in a tartaric acid-dimethylurea melt, that serves as the solvent and as the catalyst. Under these reaction conditions, sensitive functional groups such as N-Boc, N-Cbz, or azides are tolerated.

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Key Words

Fischer Indole Synthesis, Indoles


ID: J54-Y2012-2920