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A Novel System for the Synthesis of 2-Aminobenzthiazoles using Sodium Dichloroiodate

Vikas N. Telvekar*, Harshal M. Bachhav, Vinod Kumar Bairwa

*Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology, Matunga, Mumbai 400 019, India, Email: vikastelvekarrediffmail.com

V. N. Telvekar, H. M. Bachhav, V. K. Bairwa, Synlett, 2012, 23, 2219-2222.

DOI: 10.1055/s-0032-1317080


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Abstract

2-Aminobenzthiazole is a privileged scaffold with a range of biological activities. Using anilines as starting materials, a highly efficient and mild protocol enables the synthesis of 2-aminiobenzthiazoles in the presence of NaICl2.

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Key Words

synthetic methods, oxidative cyclization, sodium dichloroiodate, aniline, aminobenzthiazole, benzothiazoles


ID: J60-Y2012-3020