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Synthesis of Coumarins via Pd-Catalyzed Oxidative Cyclocarbonylation of 2-Vinylphenols

Jamie Ferguson, Fanlong Zeng and Howard Alper*

*Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada, K1N 6N5, Email: howard.alperuottawa.ca

J. Ferguson, F. Zeng, H. Alper, Org. Lett., 2012, 14, 5602-5605.

DOI: 10.1021/ol302725x (free Supporting Information)


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Abstract

Palladium-catalyzed oxidative cyclocarbonylation of 2-vinylphenols enables a direct synthesis of various coumarins in good yields in the presence of low pressures of CO, and air or 1,4- benzoquinone as the oxidant. The reaction conditions are attractive in terms of environmental considerations and operational simplicity.


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Key Words

Coumarins, Oxygen


ID: J54-Y2012-3610