Synthesis of Oxazoles from Enamides via Phenyliodine Diacetate-Mediated Intramolecular Oxidative Cyclization
Yunhui Zheng, Xuming Li, Chengfeng Ren, Daisy Zhang-Negrerie, Yunfei Du* and Kang Zhao*
*Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China, Email: duyunfeiertju.edu.cn, kangzhaotju.edu.cn
Y. Zheng, X. Li, C. Ren, D. Zhang-Negrerie, Y. Du, K. Zhao, J. Org. Chem., 2012, 77, 10353-10361.
DOI: 10.1021/jo302073e (free Supporting Information)
A broad range of functionalized oxazoles were synthesized in good yields from enamides via phenyliodine diacetate (PIDA)-mediated intramolecular cyclization. The oxidative carbon-oxygen bond formation process is heavy-metal-free.
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