Organic Chemistry Portal



Iodine-Mediated Intramolecular Electrophilic Aromatic Cyclization in Allylamines: A General Route to Synthesis of Quinolines, Pyrazolo[4,3-b]pyridines, and Thieno[3,2-b]pyridines

Harikrishna Batchu, Soumya Bhattacharyya and Sanjay Batra*

*Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, PO Box 173, Lucknow 226001, India, Email:

H. Batchu, S. Bhattacharyya, S. Batra, Org. Lett., 2012, 14, 6330-6333.

DOI: 10.1021/ol303109m (free Supporting Information)

see article for more reactions


An unprecedented synthesis of aromatic ring annulated pyridines from suitably substituted primary allylamines via intramolecular electrophilic aromatic cyclization is mediated by molecular iodine under mild conditions.

see article for more examples

Key Words


ID: J54-Y2012-3920