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Copper on Iron: Catalyst and Scavenger for Azide-Alkyne Cycloaddition

Szabolcs Kovács, Katalin Zih-Perényi, Ádám Révész, Zoltán Novák*

*Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary, Email: novakzelte.hu

S. Kovács, K. Zih-Peréni, Á. Révész, Z. Novák, Synthesis, 2012, 44, 3722-3730.

DOI: 10.1055/s-0032-1317697 (free Supporting Information)


Abstract

In the presence of a readily accessible nanosized Cu/Fe bimetallic system, Cu-catalyzed azide-alkyne cycloadditions can easily be achieved at ambient temperature with high efficiency. The catalyst produces significantly lower copper contaminants compared to homogeneous copper complexes. Iron not only behaves as support, but also acts as a redox scavenger that reduces the copper contamination of the organic product.

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Key Words

alkynes, azides, copper, iron, supported catalysis, click chemistry


ID: J66-Y2012-3960