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Pd(II)-Catalyzed Enantioselective C-H Activation/C-O Bond Formation: Synthesis of Chiral Benzofuranones

Xiu-Fen Cheng, Yan Li, Yi-Ming Su, Feng Yin, Jian-Yong Wang, Jie Sheng, Harit U. Vora, Xi-Sheng Wang* and Jin-Quan Yu

*Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China, Email: xswang77ustc.edu.cn

X.-F. Cheng, Y. Li, Y.-M. Su, F. Yin, J.-Y. Wang, J. Sheng, H. U. Vora, X.-S. Wang, J.-Q. Yu, J. Am. Chem. Soc., 2013, 135, 1236-1239.

DOI: 10.1021/ja311259x (free Supporting Information)


Abstract

Pd(II)-catalyzed C-H activation of phenylacetic acids followed by an intramolecular C-O bond formation afforded benzofuranones. A modified reaction provides the first example of enantioselective C-H functionalizations through Pd(II)/Pd(IV) redox catalysis.

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Key Words

Benzofuranones, PIDA, benzofuranones


ID: J48-Y2013-0180