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Rhodium-Catalyzed Intermolecular [2 + 2] Cycloaddition of Terminal Alkynes with Electron-Deficient Alkenes

Kazunori Sakai, Takuya Kochi and Fumitoshi Kakiuchi*

*Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan, Email: kakiuchichem.keio.ac.jp

K. Sakai, T. Kochi, F. Kakiuchi, Org. Lett., 2013, 15, 1024-1027.

DOI: 10.1021/ol303510k (free Supporting Information)


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Abstract

A catalytic intermolecular [2 + 2] cycloaddition of terminal alkynes with electron-deficient alkenes proceeds in the presence of 8-quinolinolato rhodium/phosphine catalyst system to give cyclobutenes from various substrates in high yields and with complete regioselectivity.

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Key Words

Cyclobutenes


ID: J54-Y2013-0540