Lewis Basic Selenium Catalyzed Chloroamidation of Olefins Using Nitriles as the Nucleophiles
Daniel Weiliang Tay, Ivan Tan Tsoi, Jun Cheng Er, Gulice Yiu Chung Leung* and Ying-Yeung Yeung*
*Department of Chemistry, National University of Singapore, Singapore 117543, and A*STAR−Institute of Chemical & Engineering Sciences, Singapore 138667, Email: yyyeungcuhk.edu.hk, leung_yiu_chungices.a-star.edu.sg
D. W. Tay, I. T. Tsoi, J. C. Er, G. Y. C. Leung, Y.-Y. Yeung, Org. Lett., 2013, 15, 1310-1313.
DOI: 10.1021/ol400249x (free Supporting Information)
The use of diphenyl selenide as a Lewis base catalyst enables a mild chloroamidation of a wide rand of olefinic substrates including starting materials with acid labile functional groups.
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