Gold and Palladium Combined for the Sonogashira Coupling of Aryl and Heteroaryl Halides
Biswajit Panda, Tarun K. Sarkar*
*Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India, Email: tksrchem.iitkgp.ernet.in
B. Panda, T. K. Sarkar, Synthesis, 2013, 45, 817-829.
DOI: 10.1055/s-0032-1318119 (free Supporting Information)
The orthogonal reactivity of a combination of gold and palladium catalysts shows high selectivity and extreme functional group tolerance in Sonogashira coupling of a wide array of electronically and structurally diverse substrates. A brief mechanistic study reveals that the gold acetylide intermediate enters into the palladium catalytic cycle at the transmetalation step.
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gold catalysis, cross-coupling, Sonogashira coupling