[RuCl₂(p-cymene)]₂-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Ketones under Ligand-Free and Neutral Conditions

Lei Zhang, Xiaomin Xie, Lei Fu* and Zhaoguo Zhang*

*School of Pharmacy and School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China, Email: zhaoguosjtu.edu.cn, leifuhotmail.com

L. Zhang, X. Xie, L. Fu, Z. Zhang, J. Org. Chem., 2013, 78, 3434-3437.

DOI: 10.1021/jo4001367

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Abstract

A simple and efficient Ru-catalyzed conjugate addition reaction of arylboronic acids to α,β-unsaturated ketones under neutral conditions without any additional ligands both fulfilled the inhibition of the β-hydride elimination in the catalytic cycle and minimized the protonolysis of arylboronic acids.

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Key Words

1,4-addition

ID: J42-Y2013-0930

[RuCl2(p-cymene)]2-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Ketones under Ligand-Free and Neutral Conditions

Lei Zhang, Xiaomin Xie, Lei Fu* and Zhaoguo Zhang*

[RuCl₂(p-cymene)]₂-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Ketones under Ligand-Free and Neutral Conditions