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Copper-Catalyzed Decarboxylative Coupling of Alkynyl Carboxylates with 1,1-Dibromo-1-alkenes

Zheng Huang, Rui Shang, Zi-Rong Zhang, Xiao-Dan Tan, Xiao Xiao and Yao Fu*

*Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China, Email: fuyaoustc.edu.cn

Z. Huang, R. Shang, Z.-R. Zhang, X.-D. Tan, X. Xiao, Y. Fu, J. Org. Chem., 2013, 78, 4551-4557.

DOI: 10.1021/jo400616r (free Supporting Information)


Abstract

In a copper-catalyzed decarboxylative coupling reaction, a broad range of aryl, alkenyl, alkynyl, and alkyl substituted 1,1-dibromo-1-alkenes react smoothly with aryl and alkyl substituted potassium propiolates to produce unsymmetrical 1,3-diynes and 1,3,5-triynes with high selectivity and good functional group compatibility.

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Key Words

1,3-diynes


ID: J42-Y2013