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A Mild and Efficient Flow Procedure for the Transfer Hydrogenation of Ketones and Aldehydes using Hydrous Zirconia

Claudio Battilocchio, Joel M. Hawkins and Steven V. Ley*

*Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, U.K., Email: svl1000cam.ac.uk

C. Battilocchio, J. M. Hawkins, S. V. Ley, Org. Lett., 2013, 15, 2278-2281.

DOI: 10.1021/ol400856g (free Supporting Information)


Abstract

Partially hydrated zirconium oxide as stationary heterogeneous catalyst enabled a flow chemistry Meerwein-Ponndorf-Verley (MPV) reduction procedure. The system could be applied to a wide range of functionalized substrates, allowing clean and fast delivery of the alcohol products within a few minutes.

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Key Words

Meerwein-Ponndorf-Verley (MPV) reduction, isopropanol, flow chemistry


ID: J54-Y2013