Synthesis of Iminonitriles by Oxone/TBAB-Mediated One-Pot Oxidative Three-Component Strecker Reaction
Jean-Baptiste Gualtierotti, Xavier Schumacher, Qian Wang, Jieping Zhu*
*Institute of Chemical Sciences and Engineering, Ecole
Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH 5304, 1015 Lausanne,
Switzerland, Email: jieping.zhu
epfl.ch
J.-B. Gualtierotti, X. Schumacher, Q. Wang, J. Zhu, Synthesis, 2013, 45, 1380-1386.
DOI: 10.1055/s-0032-1316908
Abstract
An oxidative Strecker reaction of aldehydes, amines, and TMSCN in a biphasic solvent system in the presence of Oxone, TBAB and sodium bicarbonate affords α-iminonitriles in good yields. This three component reaction is applicable to a wide range of aldehydes and amines.
see article for more examples
P. Fontaine, A. Chiaroni, G. Masson, J. Zhu, Org. Lett., 2008, 10, 1509-1512.
Key Words
α-iminonitriles, Oxone, α-aminonitriles, imines, nitriles, oxidative three-component Strecker reaction
ID: J66-Y2013
