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Synthesis of Aryl Thiocyanates via Copper-Catalyzed Aerobic Oxidative Cross-Coupling between Arylboronic Acids and KSCN

Nan Sun, Han Zhang, Weimin Mo, Baoxiang Hu, Zhenlu Shen, Xinquan Hu*

*College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email: xinquanzjut.edu.cn

N. Sun, H. Zhang, W. Mo, B. Hu, Z. Shen, X. Hu, Synlett, 2013, 24, 1443-1447.

DOI: 10.1055/s-0033-1338939 (free Supporting Information)


Abstract

A cross-coupling reaction of arylboronic acids with KSCN salt to yield aryl thiocyanates is catalyzed by copper acetate in the presence of 4-methylpyridine serving both as ligand and base under 0.2 MPa of molecular oxygen. Various arylboronic acids were suitable under the reaction conditions.

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Key Words

aryl thiocyanates, arylboronic acids, potassium thiocyanate, copper acetate, oxidative cross-coupling reaction, oxygen, Chan-Lam Coupling


ID: J60-Y2013