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Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex

Liang-An Chen, Weici Xu, Biao Huang, Jiajia Ma, Lun Wang, Jianwei Xi, Klaus Harms, Lei Gong* and Eric Meggers*

*Xiamen University, Xiamen, Fujian 361005, People’s Republic of China, Philipps-Universitšt Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany, Email: gonglxmu.edu.cn, meggerschemie.uni-marburg.de

L-A. Chen, W. Xu, B. Huang, J. Ma, L. Wang, J. Xi, K. Harms, L. Gong, E. Meggers, J. Am. Chem. Soc., 2013, 135, 10598-10601.

DOI: 10.1021/ja403777k (free Supporting Information)


Abstract

An inert, rigid chiral-at-metal iridium(III) complex enables a highly efficient catalytic asymmetric transfer hydrogenation of β,β-disubstituted nitroalkenes. The catalysis does not involve any direct metal coordination but operates exclusively through weak interactions with functional groups properly arranged in the ligand sphere of the iridium complex.

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Key Words

hydrogenation, Hantzsch ester


ID: J48-Y2013