A Simple One-Pot Synthesis of 2-Substituted Quinazolin-4(3H)-ones from 2-Nitrobenzamides by Using Sodium Dithionite
Angel H. Romero, José Salazar, Simón E. López*
*Departamento de Química, Edificio de Química y Procesos,
Universidad Simón Bolívar, Valle de Sartenejas, Apartado 89000, Baruta, Caracas
1080-A, Venezuela, Email: slopez
usb.ve
A. H. Romero, J. Salazar, S. E. López, Synthesis, 2013, 45, 2043-2050.
DOI: 10.1055/s-0033-1338854
Abstract
In a simple one-pot procedure for the preparation of 2-(het)arylquinazolin-4(3H)-ones from readily available 2-nitrobenzamides and aryl aldehydes, sodium dithionite is used as the reducing agent for the nitro group. Sodium dithionite also decomposes in aqueous N,N-dimethylformamide under air to form sulfur dioxide, which is the oxidant in the final oxidation step that leads to the desired heterocyclic compounds.
see article for more examples
Key Words
quinazolinones, sodium hydrosulfite, oxidations, dehydrogenations, reductions, amides, aldehydes
ID: J66-Y2013
