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Microwave-Assisted Molybdenum-Catalyzed Reductive Cyclization of o-Nitrobenzylidene Amines to 2-Aryl-2H-indazoles

Ahmed H. Moustafa, Chandi C. Malakar, Nayyef Aljaar, Elena Merisor, Jürgen Conrad, Uwe Beifuss*

*Bioorganische Chemie, Institut für Chemie, Universität Hohenheim, Garbenstr. 30, 70599 Stuttgart, Germany, Email: ubeifussuni-hohenheim.de

A. H. Moustafa, C. C. Malakar, N. Aljaar, E. Merisor, J. Conrad, U. Beifuss, Synlett, 2013, 24, 1573-1577.

DOI: 10.1055/s-0033-1339195 (free Supporting Information)


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Abstract

A reductive cyclization of o-nitrobenzylidene amines under microwave conditions in the presence of MoO2Cl2(dmf)2 as catalyst and Ph3P as reducing agent delivers 2-aryl-2H-indazoles in good yields.

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Key Words

catalysis, cyclization, 2H-indazoles, molybdenum, Schiff bases, triphenylphosphine, microwave synthesis


ID: J60-Y2013