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Synthesis of 3-Acyl-2-arylindole via Palladium-catalyzed Isocyanide Insertion and Oxypalladation of Alkyne

Takeshi Nanjo, Sho Yamamoto, Chihiro Tsukano and Yoshiji Takemoto*

*Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan, Email:

T. Nanjo, S. Yamamoto, C. Tsukano, Y. Takemoto, Org. Lett., 2013, 15, 3754-3757.

DOI: 10.1021/ol4016699 (free Supporting Information)

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Palladium-catalyzed isocyanide insertion and oxypalladation of an alkyne enables the synthesis of 3-acyl-2-arylindole derivatives. In addition, domino cyclizations for the synthesis of several tetracyclic indole derivatives were also achieved.

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Key Words


ID: J54-Y2013