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A Novel Chiral Bisphosphine-Thiourea Ligand for Asymmetric Hydrogenation of β,β-Disubstituted Nitroalkenes

Qingyang Zhao, Shengkun Li, Kexuan Huang, Rui Wang* and Xumu Zhang*

*Lanzhou University, Lanzhou 730000, China; Rutgers, The State University of New Jersey, New Jersey 08854, United States, Email: wangruilzu.edu.cn; xumurci.rutgers.edu

Q. Zhao, S. Li, K. Huang, R. Wang, X. Zhang, Org. Lett., 2013, 15, 4014-4017.

DOI: 10.1021/ol401816y (free Supporting Information)


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Abstract

A chiral bisphosphine-thiourea ligand was applied in the highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes. The thiourea group of the ligand takes on an important role in this catalytic system as a H-bond donor.

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Key Words

hydrogenation, hydrogen


ID: J54-Y2013