A Pd(0)-Catalyzed Direct Dehydrative Coupling of Terminal Alkynes with Allylic Alcohols To Access 1,4-Enynes
Yang-Xiong Li, Qing-Qing Xuan, Li Liu*, Dong Wang, Yong-Jun Chen and Chao-Jun Li*
*Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; McGill University, Sherbrook Street West, Montreal, Quebec, Canada H3A 0B8, Email: lliuiccas.ac.cn; firstname.lastname@example.org
Y.-X. Li, Q.-Q. Xuan, L. Liu, D. Wang, Y.-J. Chen, C.-J. Li, J. Am. Chem. Soc., 2013, 135, 12536-12539.
DOI: 10.1021/ja406025p (free Supporting Information)
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A direct dehydrative coupling of terminal alkynes with allylic alcohols is catalyzed by Pd(PPh3)4 in the presence of an N,P-ligand and Ti(OiPr)4. The coupling reaction tolerates various functional groups and provides a valuable synthetic tool to access 1,4-enynes.
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